MODEL-BASED ADAPTIVE CLOSED-LOOP FEEDBACK-CONTROL OF ATRACURIUM-INDUCED NEUROMUSCULAR BLOCKADE

被引：24

作者：

OLKKOLA, KT ^{[1
]}

SCHWILDEN, H ^{[1
]}

APFFELSTAEDT, C ^{[1
]}

机构：

[1] UNIV BONN,DEPT ANESTHESIOL,W-5300 BONN,GERMANY

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1991年 / 35卷 / 05期

关键词：

ATRACURIUM; COMPUTERS; EQUIPMENT; MODELS; NEUROMUSCULAR RELAXANTS; PHARMACOKINETICS;

D O I：

10.1111/j.1399-6576.1991.tb03321.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Closed-loop control of atracurium-induced neuromuscular blockade by a model-based adaptive feedback algorithm is described. Mean offsets (+/- s.d.) from setpoints at 50, 70 and 90% neuromuscular blocks using the Relaxograph(R) were 1.1 +/- 1.3, 0.2 +/- 0.7 and 0.1 +/- 0.4%, respectively. Correspondingly, the mean steady-state rates of infusion of atracurium were 0.20 +/- 0.06, 0.25 +/- 0.03 and 0.39 +/- 0.10 mg.kg-1.h-1. The described controller provides reasonable control of atracurium dosing at different degrees of neuromuscular blockade. It gives a solution to the problem of adapting pharmacokinetic and pharmacodynamic data to individuals when using population mean data as starting values for drug therapy.

引用

页码：420 / 423

页数：4

共 14 条

[1] MONITORING OF NEUROMUSCULAR FUNCTION [J].