RAPID AND RELIABLE INDUCTION OF PARTIAL STATUS EPILEPTICUS IN NAIVE RATS BY LOW-FREQUENCY (3-HZ) STIMULATION OF THE AMYGDALA

被引：5

作者：

CAIN, DP

MCKITRICK, DJ

BOON, F

机构：

[1] Department of Psychology, University of Western Ontario, London

来源：

EPILEPSY RESEARCH | 1992年 / 12卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

AMYGDALA STIMULATION; LOW-FREQUENCY STIMULATION; STATUS EPILEPTICUS; RAT;

D O I：

10.1016/0920-1211(92)90091-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Naive rats were electrically stimulated in the amygdala with biphasic square wave pulses at 3 Hz in a model of partial status epilepticus (SE). This treatment led to the rapid kindling of seizures in all rats, and the subsequent induction of SE in 100% of rats stimulated for approximately 30-60 min. Extensive gliosis and degeneration was seen in the basal forebrain of the SE brains. This method of inducing SE is simpler, more rapid, and more reliable than similar methods reported previously.

引用

页码：51 / 55

页数：5

共 9 条

[1] KINDLING WITH LOW-FREQUENCY STIMULATION - GENERALITY, TRANSFER, AND RECRUITING EFFECTS [J].