PRIMARY CONTRIBUTION OF THE INJECTOR TO CARRYOVER OF A TRACE ANALYTE IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：13

作者：

SAHA, M

GIESE, RW

机构：

[1] NORTHEASTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,DEPT PHARMACEUT SCI,BOSTON,MA 02115

[2] NORTHEASTERN UNIV,BARNETT INST CHEM ANAL & MAT SCI,BOSTON,MA 02115

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 631卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(93)80515-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

When a low-nanogram amount of N1,N3-bis-(pentafluorobenzyl)-N7-(2-[pentafluorobenzyloxy]ethyl)xanthine was subjected to HPLC, low-picogram amounts of the compound could be detected subsequently (off-line by gas chromatography-electron-capture negative-ion mass spectrometry) after injection of pure mobile phase. This was in spite of significant, intermediate washing of the injector and column. It was determined that essentially 99.9% of this analyte contamination came from the injector. Use of two injectors is a practical remedy for this problem.

引用

页码：161 / 163

页数：3

共 5 条

[1]

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[2]

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[3]

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[4] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY VERSUS SOLID-PHASE EXTRACTION FOR POST-DERIVATIZATION CLEANUP PRIOR TO GAS-CHROMATOGRAPHY ELECTRON-CAPTURE NEGATIVE-ION MASS-SPECTROMETRY OF N1,N3-BIS-(PENTAFLUOROBENZYL)-N7-(2-[PENTAFLUOROBENZYLOXY]ETHYL)XANTHINE, A PRODUCT DERIVED FROM AN ETHYLENE-OXIDE DNA ADDUCT [J].

SAHA, M ;

GIESE, RW .

JOURNAL OF CHROMATOGRAPHY, 1993, 629 (01) :35-40

[5]

SIMONSON L, 1992, LC GC-MAG SEP SCI, V10, P533

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