APAMIN INCREASES NMDA-INDUCED BURST-FIRING OF RAT MESENCEPHALIC DOPAMINE NEURONS

被引：93

作者：

SEUTIN, V ^{[1
]}

JOHNSON, SW ^{[1
]}

NORTH, RA ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV, VOLLUM INST, PORTLAND, OR 97201 USA

来源：

BRAIN RESEARCH | 1993年 / 630卷 / 1-2期

关键词：

APAMIN; VENTRAL TEGMENTAL AREA; BURST-FIRING;

D O I：

10.1016/0006-8993(93)90675-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-D-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

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页码：341 / 344

页数：4

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