BIDIRECTIONAL EFFECTS OF INTRATHECAL NMDA AND SUBSTANCE-P ON RAT DORSAL HORN NEURONAL RESPONSES

被引：16

作者：

CHAPMAN, V

DICKENSON, AH

TJOLSEN, A

机构：

[1] UCL, DEPT PHARMACOL, LONDON WC1E 6BT, ENGLAND

[2] UNIV BERGEN, DEPT PHYSIOL, N-5009 BERGEN, NORWAY

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期

关键词：

RAT; DORSAL HORN; NOCICEPTION; N-METHYL-D-ASPARTATE; SUBSTANCE P;

D O I：

10.1016/0304-3940(94)90297-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and A delta-fibre evoked responses but not wind-up of convergent dorsal born neurones in the halothane anaesthetized rat. Higher doses of NMDA and SP (10-500 ng) were without effect. Co-administered SP (10 ng) with NMDA (5 ng) facilitated A delta-fibre evoked responses and wind-up. Excitatory amino acid and peptide interactions are discussed.

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页码：90 / 94

页数：5

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