CONGESTIVE-HEART-FAILURE AFTER SURGICAL-CORRECTION OF MITRAL REGURGITATION - A LONG-TERM STUDY

被引:99
作者
ENRIQUEZSARANO, M
SCHAFF, HV
ORSZULAK, TA
BAILEY, KR
TAJIK, AJ
FRYE, RL
机构
[1] MAYO CLIN & MAYO FDN,CARDIOVASC SURG SECT,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,BIOSTAT SECT,ROCHESTER,MN 55905
关键词
FOLLOW-UP STUDIES; HEART FAILURE; MITRAL VALVE; PROGNOSIS; SURGERY;
D O I
10.1161/01.CIR.92.9.2496
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background In patients with mitral regurgitation, surgical intervention produces immediate improvement in symptoms, but the long-term incidence and significance of postoperative congestive heart failure are unknown. Methods and Results The long-term outcome of 576 operative survivors of surgical correction of pure mitral regurgitation performed between 1980 and 1989 was analyzed. Survival was 77+/-2% and 56+/-3% at 5 and 10 years, respectively Cumulative incidence of congestive heart failure was 23+/-2%, 33+/-3%, and 37+/-3% at 5, 10; and 14 years, respectively; Survival after the first episode of congestive heart failure was dismal, 44+/-4% at 5 years. Cause of congestive heart failure was left ventricular dysfunction in two thirds of the patients and valvular dysfunction in the other third With multivariate analysis, the independent predictors of postoperative heart failure were preoperative ejection fraction (P=.001), coronary artery disease (P=.0017), and New York Heart Association functional class (P=.012), with borderline value for atrial fibrillation (P=.10). The performance of valve repair was independently predictive of a lower incidence of the combined end point of death and heart failure (P=.001), compared with valve replacement. Conclusions Congestive heart failure frequently occurs late after surgical correction of mitral regurgitation and portends dismal prognosis. This complication is due most often to left ventricular dysfunction; its main determinant is decreased left ventricular function preoperatively. These data should lead to earlier indication of surgical correction of mitral regurgitation, before left ventricular dysfunction occurs.
引用
收藏
页码:2496 / 2503
页数:8
相关论文
共 47 条
  • [1] BRAUNWALD E, 1992, HEART DISEASE TXB CA, P1018
  • [2] MITRAL-VALVE REPLACEMENT - 9-YEAR FOLLOW-UP OF RISKS AND SURVIVALS
    CHAFFIN, JS
    DAGGETT, WM
    [J]. ANNALS OF THORACIC SURGERY, 1979, 27 (04) : 312 - 319
  • [3] APPLICABILITY OF MITRAL VALVULOPLASTY TECHNIQUES IN A NORTH-AMERICAN POPULATION
    CHAVEZ, AM
    COSGROVE, DM
    LYTLE, BW
    GILL, CC
    LOOP, FD
    STEWART, RW
    GOLDING, LR
    TAYLOR, PC
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1988, 62 (04) : 253 - 256
  • [4] A COMPARISON OF ENALAPRIL WITH HYDRALAZINE ISOSORBIDE DINITRATE IN THE TREATMENT OF CHRONIC CONGESTIVE-HEART-FAILURE
    COHN, JN
    JOHNSON, G
    ZIESCHE, S
    COBB, F
    FRANCIS, G
    TRISTANI, F
    SMITH, R
    DUNKMAN, WB
    LOEB, H
    WONG, ML
    BHAT, G
    GOLDMAN, S
    FLETCHER, RD
    DOHERTY, J
    HUGHES, CV
    CARSON, P
    CINTRON, G
    SHABETAI, R
    HAAKENSON, C
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (05) : 303 - 310
  • [5] COHN LH, 1985, J THORAC CARDIOV SUR, V90, P872
  • [6] THE RELATIONSHIP OF AFTERLOAD TO EJECTION PERFORMANCE IN CHRONIC MITRAL REGURGITATION
    CORIN, WJ
    MONRAD, ES
    MURAKAMI, T
    NONOGI, H
    HESS, OM
    KRAYENBUEHL, HP
    [J]. CIRCULATION, 1987, 76 (01) : 59 - 67
  • [7] DETERMINANTS OF SURVIVAL AND LEFT-VENTRICULAR PERFORMANCE AFTER MITRAL-VALVE REPLACEMENT
    CRAWFORD, MH
    SOUCHEK, J
    OPRIAN, CA
    MILLER, DC
    RAHIMTOOLA, S
    GIACOMINI, JC
    SETHI, G
    HAMMERMEISTER, KE
    [J]. CIRCULATION, 1990, 81 (04) : 1173 - 1181
  • [8] DELOCHE A, 1990, J THORAC CARDIOV SUR, V99, P990
  • [9] ENRIQUEZSARANO M, 1983, ARCH MAL COEUR VAISS, V76, P1194
  • [10] VALVE REPAIR IMPROVES THE OUTCOME OF SURGERY FOR MITRAL REGURGITATION - A MULTIVARIATE-ANALYSIS
    ENRIQUEZSARANO, M
    SCHAFF, HV
    ORSZULAK, TA
    TAJIK, AJ
    BAILEY, KR
    FRYE, RL
    [J]. CIRCULATION, 1995, 91 (04) : 1022 - 1028