LIPOPOLYSACCHARIDE-INDUCED APOPTOSIS IN SWINE LYMPHOCYTES IN-VIVO

被引:49
作者
NORIMATSU, M [1 ]
ONO, T [1 ]
AOKI, A [1 ]
OHISHI, K [1 ]
TAKAHASHI, T [1 ]
WATANABE, G [1 ]
TAYA, K [1 ]
SASAMOTO, S [1 ]
TAMURA, Y [1 ]
机构
[1] TOKYO UNIV AGR & TECHNOL, VET PHYSIOL LAB, FUCHU, TOKYO 183, JAPAN
关键词
D O I
10.1128/IAI.63.3.1122-1126.1995
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The in vivo effects of bacterial lipopolysaccharide (LPS) on the immune systems of piglets were investigated. Intravenous injection of 0.5 mg of LPS per kilogram of body weight induced apoptosis, which was characterized by nuclear chromatin condensation and fragmentation and a ladder formation of nucleosomal DNA in lymphocytes both in the cortex of the thymus and in the germinal centers and paracortical areas of mesenteric lymph nodes at 24 h postinjection. The levels of endotoxin, tumor necrosis factor alpha, and cortisol in serum increased, generally according to the dose of LPS. These findings suggest that LPS can induce in vivo apoptosis of lymphocytes in piglets and support the notion that cytokine and endocrine responses may play an important role in LPS-induced apoptosis in the immune system.
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收藏
页码:1122 / 1126
页数:5
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