SIGNIFICANCE OF HIGH-LEVELS OF SERUM IGA AND IGA-CLASS CIRCULATING IMMUNE-COMPLEXES (IGA-CIC) IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS

被引：24

作者：

EGUCHI, K ^{[1
]}

YAGAME, M ^{[1
]}

SUZUKI, D ^{[1
]}

JINDE, K ^{[1
]}

NAKA, R ^{[1
]}

YANO, N ^{[1
]}

NOMOTO, Y ^{[1
]}

SAKAI, H ^{[1
]}

MIYAZAKI, M ^{[1
]}

机构：

[1] TOKAI UNIV,SCH MED,DEPT INTERNAL MED,DIV NEPHROL & METAB,ISEHARA,KANAGAWA 25911,JAPAN

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 1995年 / 9卷 / 01期

关键词：

D O I：

10.1016/1056-8727(94)00002-6

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Significance of serum IgA and IgA-class circulating immune complexes (IgA-CIC) elevation in patients with non-insulin-dependent diabetes mellitus (NIDDM) was described. Seventeen patients with NIDDM and 17 patients with diffuse mesangial proliferative glomerulonephritis without deposition of IgA (DPGN) as controls were examined. The levels of serum IgA in patients with NIDDM were significantly higher than those in patients with DPGN (p less than or equal to 0.01). The levels of IgA-CIC in patients with NIDDM were also significantly higher than those in patients with DPGN (p less than or equal to 0.01). Production of IgA derived from B cells and the proportion of IgA bearing B cells in patients with NIDDM were not significantly higher than those in patients with DPGN. Furthermore, the levels of IgA in pharyngeal washings from diabetic patients were not significantly higher than those for DPGN patients. Duration of diabetes, the level of HbA(1c), and the presence of hypertension, microalbuminuria, or retinopathy showed no significant correlations with the levels of serum IgA or IgA-CIC in patients with NIDDM. It was postulated that the elevations of serum IgA and IgA-CIC were based on subclinical infection of the mucosa and/or deterioration of IgA clearance in patients with NIDDM.

引用

页码：42 / 48

页数：7

共 11 条

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