ACIDIC FIBROBLAST GROWTH-FACTOR PREVENTS DEATH OF SPINAL-CORD MOTONEURONS IN NEWBORN RATS AFTER NERVE-SECTION

被引：26

作者：

CUEVAS, P ^{[1
]}

CARCELLER, F ^{[1
]}

GIMENEZGALLEGO, C ^{[1
]}

机构：

[1] CSIC,CTR INVEST BIOL,MADRID,SPAIN

来源：

NEUROLOGICAL RESEARCH | 1995年 / 17卷 / 05期

关键词：

FIBROBLAST GROWTH FACTOR; SPINAL MOTONEURON RESCUE; ULNAR AND MEDIAN NERVES AXOTOMY;

D O I：

10.1080/01616412.1995.11740350

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The death of spinal axotomised motoneurons provides a useful tool for studying neurotrophic factors which could prevent motoneuron loss in vivo. Median and ulnar nerves of newborn rats were unilaterally sectioned and topically treated with either a vehicle solution or acidic fibroblast growth factor (aFGF), aFGF treatment increased the survival of the median and ulnar spinal motoneurons, after 7 days of axotomy, from 37% to 63%. These results show that aFGF is a neurotrophic factor for newborn spinal motoneurons, and suggest that this protein is a potential therapeutic agent for preventing the death of damaged motoneurons.

引用

页码：396 / 399

页数：4

共 27 条

[1] NEUROTROPHIC FACTORS ENTER THE CLINIC [J].