ORAL-ADMINISTRATION OF L-ARGININE AND CAPTOPRIL IN RATS PREVENTS CHRONIC-RENAL-FAILURE BY NITRIC-OXIDE PRODUCTION

被引：124

作者：

ASHAB, I ^{[1
]}

PEER, G ^{[1
]}

BLUM, M ^{[1
]}

WOLLMAN, Y ^{[1
]}

CHERNIHOVSKY, T ^{[1
]}

HASSNER, A ^{[1
]}

SCHWARTZ, D ^{[1
]}

CABILI, S ^{[1
]}

SILVERBERG, D ^{[1
]}

IAINA, A ^{[1
]}

机构：

[1] TEL AVIV MED CTR & SCH MED,DEPT NEPHROL,IL-64239 TEL AVIV,ISRAEL

来源：

KIDNEY INTERNATIONAL | 1995年 / 47卷 / 06期

关键词：

D O I：

10.1038/ki.1995.214

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of oral supplementation of L-arginine, the substrate of nitric oxide, (1.25 g/liter water) and captopril (15 mg/liter water) was studied in 5/6 nephrectomized rats for a period of three months. N-omega-nitro L-arginine, a nitric oxide synthase inhibitor, was given orally (70 mg/liter water) with or without L-arginine or captopril. The urinary excretion of nitrite (NO2) + nitrate (NO3), the known metabolites of nitric oxide, was taken as an index of nitric oxide production. Chronic renal failure rats were characterized by a low creatinine clearance, high FE(Na)%, proteinuria, hypertension and a low urinary excretion of NO2 + NO3: 0.152 +/- 0.06 (P < 0.001) nmol/mu g creatinine compared with 0.481 +/- 0.004 (P < 0.001) in normal rats and 0.479 +/- 0.11 (P < 0.001) in untreated sham-operated rats. Both L-arginine and captopril were effective in the normalization of all these parameters. The combination of L-arginine and captopril had no additive effects. The nitric oxide synthase inhibitor significantly diminished the captopril beneficial effect. It is concluded that chronic-renal failure in rats is a low nitric oxide production state. The supplementation of L-arginine is shown to overcome this condition. It is suggested that the beneficial effect of captopril on chronic renal failure is through a specific L-arginine-nitric oxide synthase-nitric oxide pathway.

引用

页码：1515 / 1521

页数：7

共 26 条

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