INTERFERON-ALPHA AND INTERFERON-BETA DOWN-REGULATE THE EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN CARCINOMAS

被引：393

作者：

SINGH, RK ^{[1
]}

GUTMAN, M ^{[1
]}

BUCANA, CD ^{[1
]}

SANCHEZ, R ^{[1
]}

LLANSA, N ^{[1
]}

FIDLER, IJ ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期

关键词：

ANGIOGENESIS;

D O I：

10.1073/pnas.92.10.4562

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Downregulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (>10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

引用

页码：4562 / 4566

页数：5

共 34 条

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