SINGLE-FIBER ELECTROMYOGRAPHY IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS

被引：27

作者：

VERSCHUUREN, JJGM

SPAANS, F

DEBAETS, MH

机构：

[1] STATE UNIV LIMBURG,DEPT IMMUNOL,POB 616,6200 MD MAASTRICHT,NETHERLANDS

[2] STATE UNIV LIMBURG,DEPT CLIN NEUROPHYSIOL,6200 MD MAASTRICHT,NETHERLANDS

来源：

MUSCLE & NERVE | 1990年 / 13卷 / 06期

关键词：

acetylcholine receptor; autoimmunity; decrement studies; myasthenia gravis; single fiber electromyography;

D O I：

10.1002/mus.880130604

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The sensitivity of stimulated single‐fiber electromyography in the detection of early abnormalities in neuromuscular transmission in experimental autoimmune myasthenia gravis (EAMG) was tested. Increased jitter and blocking were seen up to 3 weeks before clinical illness or decrement developed. Stimulation at 10 Hz appeared more sensitive in detection of abnormalities than stimulation at 3 or 5 Hz. Jitter values did not correlate with anti‐Torpedo acetylcholine receptor (AChR), nor with anti‐rat AChR antibody titer. No correlation was found between jitter and AChR loss or AChR‐antibody complexes in muscle. It is concluded that, in addition to AChR loss and the presence of AChR‐Antibody complexes, other factors must determine the neuromuscular dysfunction in EAMG and possibly myasthenia gravis. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：485 / 492

页数：8

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[3]

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