CONTROLLED-STUDY OF THE EFFECT OF SULFINPYRAZONE ON PLATELET SURVIVAL AND ON PLATELET-BOUND SEROTONIN-C-14 RELEASE IN PATIENTS WITH PREVIOUS MYOCARDIAL-INFARCTION

被引：4

作者：

CORTELLARO, M ^{[1
]}

BOSCHETTI, C ^{[1
]}

FASSIO, G ^{[1
]}

BASAGNI, M ^{[1
]}

POLLI, EE ^{[1
]}

机构：

[1] UNIV MILAN,CATTEDRA IST MATEMAT MED,I-20122 MILAN,ITALY

来源：

ACTA HAEMATOLOGICA | 1979年 / 61卷 / 02期

关键词：

Hyperbetalipoproteinemia; Myocardial infarction; Platelet serotonin release; Platelet survival; Sulfinpyrazone;

D O I：

10.1159/000207634

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preliminary data obtained in the ambit of Anturan Reinfarction Italian Study (ARIS) show that, in postmyocardial infarction, reduced platelet survival time occurred in hyperbetalipoproteinemic palients treated with placebo, but not in the group of patients treated with sulfinpyrazone (interaction between treatment and lipemic level is at p ~ 0.1). The sulfinpyrazone effect on platelet survival is probably related to the release reaction inhibition as suggested by our ex vivo results on platelet-bound 14C-serotonin release. © 1979 S. Karger AG, Basel.

引用

页码：68 / 74

页数：7

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