ANTI-AIDS AGENTS .3. INHIBITORY EFFECTS OF COLCHICINE DERIVATIVES ON HIV REPLICATION IN H9 LYMPHOCYTE-CELLS

被引：14

作者：

TATEMATSU, H

KILKUSKIE, RE

CORRIGAN, AJ

BODNER, AJ

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 02期

关键词：

D O I：

10.1021/np50074a052

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.

引用

页码：632 / 637

页数：6

共 13 条

[1]

BAUM R, 1989, CHEM IND-LONDON, P7

[2] BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES .2. EVALUATION OF CATECHOLIC COLCHICINES, COLCHIFOLINES, COLCHICIDE, AND NOVEL N-ACYL-AROYLDEACETYLCOLCHICINE AND N-AROYLDEACETYLCOLCHICINE [J].

BROSSI, A ;

SHARMA, PN ;

ATWELL, L ;

JACOBSON, AE ;

IORIO, MA ;

MOLINARI, M ;

CHIGNELL, CF .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (10) :1365-1369

[3] SIMPLE CONVERSION OF COLCHICINE INTO DEMECOLCINE [J].

CAPRARO, HG ;

BROSSI, A .

HELVETICA CHIMICA ACTA, 1979, 62 (04) :965-970

[4] ZUR DARSTELLUNG DER TRIMETHYL-COLCHICINSAURE [J].

FERNHOLZ, H .

ANGEWANDTE CHEMIE, 1953, 65 (12) :319-319

[5]

HOUSSET E, 1967, ANN DERMATOL SYPHIL, V94, P31

[6]

KEREKES P, 1985, J MED CHEM, V28, P1204

[7] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF CHLOROETHYLUREA, METHYLUREA, AND NITROSOUREA ANALOGS OF N-DEACETYLMETHYLTHIOCOLCHICINE [J].

LIN, TS ;

SHIAU, GT ;

PRUSOFF, WH ;

HARMON, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1440-1442

[8]

MUZAFFAR A, 1989, HETEROCYCLES, V28, P365

[9] ANTI-AIDS AGENTS .2. INHIBITORY EFFECTS OF TANNINS ON HIV REVERSE-TRANSCRIPTASE AND HIV REPLICATION IN H9 LYMPHOCYTE-CELLS [J].

NONAKA, G ;

NISHIOKA, I ;

NISHIZAWA, M ;

YAMAGISHI, T ;

KASHIWADA, Y ;

DUTSCHMAN, GE ;

BODNER, AJ ;

KILKUSKIE, RE ;

CHENG, YC ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (03) :587-595

[10]

READ S, 1989, 5TH INT C AIDS MONTR, P528

← 1 2 →