DETECTION OF EPSTEIN-BARR-VIRUS GENOMES IN HODGKINS-DISEASE - RELATION TO AGE

被引：156

作者：

JARRETT, RF

GALLAGHER, A

JONES, DB

ALEXANDER, FE

KRAJEWSKI, AS

KELSEY, A

ADAMS, J

ANGUS, B

GLEDHILL, S

WRIGHT, DH

CARTWRIGHT, RA

ONIONS, DE

机构：

[1] UNIV SOUTHAMPTON,ROYAL SOUTHANTS HOSP,DEPT MED ONCOL,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

[2] LEUKAEMIA RES FUND,CTR CLIN EPIDEMIOL,LEEDS,ENGLAND

[3] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,DEPT PATHOL,SOUTHAMPTON S09 4XY,ENGLAND

[4] UNIV NEWCASTLE UPON TYNE,DEPT PATHOL SCI,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[5] UNIV EDINBURGH,SCH MED,DEPT PATHOL,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[6] ROYAL MANCHESTER CHILDRENS HOSP,DEPT HISTOPATHOL,MANCHESTER M27 1HA,LANCS,ENGLAND

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1991年 / 44卷 / 10期

关键词：

D O I：

10.1136/jcp.44.10.844

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

An investigation as to whether any partiCular subgroup of patients with Hodgkin's disease was particularly likely to be Epstein-Barr virus (EBV) genome positive was made on samples from 95 patients. These were grouped according to age and Hodgkin's disease subtype, and analysed using Southern blot analysis. Most samples from children or adults aged 50 years or over contained detectable EBV genomes; samples from young adults were only rarely positive. The differences in EBV positivity by age were highly significant, but there was no significant association between EBV and histological subtype after allowing for the effect of age. The results support the hypothesis that Hodgkin's disease in different age groups may have different aetiologies, and suggest that EBV does have a pathogenetic role in Hodgkin's disease in children and older age groups.

引用

页码：844 / 848

页数：5

共 42 条

[1] A SPECIALIST LEUKEMIA LYMPHOMA REGISTRY IN THE UK .2. CLUSTERING OF HODGKINS-DISEASE [J].