MONOCYTIC DIFFERENTIATION INDUCTION OF HL-60 CELLS BY MC-903, A NOVEL VITAMIN-D ANALOG

被引：19

作者：

REBEL, VI ^{[1
]}

OSSENKOPPELE, GJ ^{[1
]}

VANDELOOSDRECHT, AA ^{[1
]}

WIJERMANS, PW ^{[1
]}

BEELEN, RHJ ^{[1
]}

LANGENHUIJSEN, MMAC ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM HOSP,DEPT CELL BIOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

LEUKEMIA RESEARCH | 1992年 / 16卷 / 05期

关键词：

HL-60; CELLS; MC-903; MONOCYTIC DIFFERENTIATION;

D O I：

10.1016/0145-2126(92)90169-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1.25 (OH)2D3 is a potent inducer of differentiation of leukaemic cells into a monocytic direction. However, therapeutic application is difficult because of the development of hypercalcaemia. We examined a novel vitamin D analogue, MC 903, which is at least 100 times less effective on calcium metabolism in rats than 1.25 (OH)2D3. Using the HL-60 cell line, differentiation was measured with a comprehensive panel of qualitative and quantitative parameters. Development of monocytic cells was shown morphologically, immunophenotypically and functionally by increased capability of reducing NBT (vs cultures without MC 903, p < 0.0001) and by qualitatively and quantitatively increased non-specific esterase activity. Furthermore, a concomitant decreased activity of myeloperoxidase and lactate dehydrogenase was noticed. In conclusion, MC 903 is a potent inducer of monocytic differentiation, comparable with 1.25 (OH)2D3 and will therefore be an interesting and potential therapeutic agent for studies in human acute leukaemia.

引用

页码：443 / 451

页数：9

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