DELINEATION OF AN EXTENDED SURFACE-CONTACT AREA ON HUMAN CD4 INVOLVED IN CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX BINDING

被引：81

作者：

MOEBIUS, U

PALLAI, P

HARRISON, SC

REINHERZ, EL

机构：

[1] HOWARD HUGHES MED INST, CAMBRIDGE, MA 02138 USA

[2] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[4] HARVARD UNIV, DEPT BIOCHEM & MOLEC BIOL, CAMBRIDGE, MA 02138 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 17期

关键词：

CD4; MUTAGENESIS; T-CELL FUNCTION; AIDS;

D O I：

10.1073/pnas.90.17.8259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe a detailed mapping of the class II major histocompatibility complex (MHC) binding site using site-directed mutagenesis in conjunction with high-resolution CD4 structural data. Residues on all lateral surfaces of domain 1 and the neighboring portions of domain 2 participate in contacting class II MHC. Thus, in addition to the C'C'' ridge that forms the human immunodericiency virus type 1 gp120 binding site, apparent MHC contacts extend over the BED face of domain 1 and across the interdomain groove onto the FG loop of domain 2. Several models of the CD4/class II MHC interaction accounting for the extent of the CD4 surface involved are discussed, including the possibility that CD4 may contact more than one class II MHC molecule using different surfaces.

引用

收藏

页码：8259 / 8263

页数：5

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