IOPRONIC ACID INTERACTION WITH HEPATIC MICROSOMAL CYTOCHROME-P-450 - RELATIONSHIP BETWEEN CHEMICAL-STRUCTURE AND BINDING

被引：10

作者：

FACINO, RM ^{[1
]}

RAFFAELI, E ^{[1
]}

PITRE, D ^{[1
]}

机构：

[1] BRACCO IND CHIM,RIC LAB,F-20134 MILANO,ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0031-6989(79)80064-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction of the cholecystographic agent Iopronic acid with cytochrome P-450 from rat liver microsomes has been examined in the light of the hydrophobic properties and of the nucleophilic and steric features of the molecule. The lipophilic character and binding parameters with cytochrome P-450 (ΔA max, Ks) of Iopronic acid and some selected congeners were analyzed and these showed that the intrinsic lipophilic nature and the steric parameters of the molecule play key roles in determining the type of binding and the affinity with which the compound interacts with cytochrome P-450. © 1979 The Italian Pharmacological Society.

引用

页码：105 / 114

页数：10

共 21 条

[1]

BINNS TB, 1964, ABSORPTION DISTRIBUT, P30

[2]

FELDER E, 1976, FARMACO-ED SCI, V31, P349

[3]

FELDER E, 1973, FARM ED PRAT, V28, P485

[4] INTERACTION OF AROMATIC-HYDROCARBONS AND DRUGS WITH ADRENAL MICROSOMAL CYTOCHROME-P-450 IN GUINEA-PIG [J].