HYPERIMMUNOGLOBULIN-E SYNDROME - RESPONSE TO TRANSFER-FACTOR AND ASCORBIC-ACID THERAPY

This report presents the case history of a 29-year-old man with hyperimmunoglobulin E syndrome and the successful treatment with transfer factor and ascorbic acid. The patient presented with a marked defect in the ability of his lymphocytes to respond to mitogens, in skin test response to DNCB challenge and other recall antigens, and a variety of in vitro granulocyte function defects. The presence of a serum inhibitor to lymphocyte and granulocyte function was found. This individual had multiple episodes of mucocutaneous candidiasis and staphylococcal infections. Clinical improvement was evident after transfer factor and ascorbic acid treatment. Many of the in vitro functions also returned to normal. © 1979.