DIURNAL MELATONIN RHYTHM IN PRIMATE CEREBROSPINAL-FLUID

被引：144

作者：

REPPERT, SM ^{[1
]}

PERLOW, MJ ^{[1
]}

TAMARKIN, L ^{[1
]}

KLEIN, DC ^{[1
]}

机构：

[1] ST ELIZABETHS HOSP,NIMH,CLIN PSYCH PHARMACOL LAB,WASHINGTON,DC 20032

来源：

ENDOCRINOLOGY | 1979年 / 104卷 / 02期

关键词：

D O I：

10.1210/endo-104-2-295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melatonin was measured in cerebrospinal fluid (CSF) withdrawn continuously from partially restrained rhesus monkeys. There was a daily rhythm in CSF melatonin with peak night values 2- to >15-fold higher than day values. The increase occurred shortly after lights were turned off, and the decrease occurred soon after lights were turned on. There was substantial variation in the magnitude of the rhythm among animals. However, there was little day to day variation in the rhythm of individual animals studied for 3 or 6 consecutive days. Although the concentration of melatonin in CSF was lower than that in plasma, the changes in CSF melatonin concentrations seemed to reflect large daily changes in plasma melatonin concentrations. © 1979 by The Endocrine Society.

引用

页码：295 / 301

页数：7

共 27 条

[1] MELATONIN RADIOIMMUNOASSAY [J].

ARENDT, J ;

PAUNIER, L ;

SIZONENKO, PC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 40 (02) :347-350

[2]

ARENDT J, 1977, HORMONE RES, V8, P67

[3] BINDING OF MELATONIN TO HUMAN AND RAT PLASMA-PROTEINS [J].

CARDINALI, DP ;

WURTMAN, RJ ;

LYNCH, HJ .

ENDOCRINOLOGY, 1972, 91 (05) :1213-+

[4] MELATONIN - DAILY CYCLE IN PLASMA AND CEREBROSPINAL-FLUID OF CALVES [J].

HEDLUND, L ;

LISCHKO, MM ;

ROLLAG, MD ;

NISWENDER, GD .

SCIENCE, 1977, 195 (4279) :686-687

[5]

HIRATA F, 1974, J BIOL CHEM, V249, P1311

[6] SPECIFIC RADIOIMMUNOASSAY FOR MELATONIN IN BIOLOGICAL TISSUE AND FLUIDS AND ITS VALIDATION BY GAS CHROMATOGRAPHY MASS SPECTROMETRY [J].

KENNAWAY, DJ ;

FRITH, RG ;

PHILLIPOU, G ;

MATTHEWS, CD ;

SEAMARK, RF .

ENDOCRINOLOGY, 1977, 101 (01) :119-127

[7]

KLEIN DC, 1978, HYPOTHALAMUS, P303

[8]

KOPIN IJ, 1961, J BIOL CHEM, V236, P3972

[9]

KVEDER S, 1961, J BIOL CHEM, V236, P3214

[10] ANALYSIS OF MELATONIN IN HUMAN-PLASMA BY GAS-CHROMATOGRAPHY NEGATIVE CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

LEWY, AJ ;

MARKEY, SP .

SCIENCE, 1978, 201 (4357) :741-743

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