CHIRAL DIFFERENTIATION IN THE DEACYLATION OF 6A-O-(2-[4-(2-METHYLPROPYL)PHENYL]PROPANOYL)-BETA-CYCLODEXTRIN

被引：13

作者：

COATES, JH ^{[1
]}

EASTON, CJ ^{[1
]}

VANEYK, SJ ^{[1
]}

MAY, BL ^{[1
]}

SINGH, P ^{[1
]}

LINCOLN, SF ^{[1
]}

机构：

[1] UNIV ADELAIDE,DEPT CHEM,GPO BOX 498,ADELAIDE,SA 5001,AUSTRALIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 11期

关键词：

D O I：

10.1039/c39910000759

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In 0.1 mol dm-3 sodium carbonate buffer at pH 11.5 the pseudo first-order rate constants for the hydrolysis of the diastereoisomers of the title compound to give lbuprofen {2-[4-(2-methylpropyl)phenyl]propanoic acid} and beta-cyclodextrin are 2.97 x 10(-5) s-1 and 3.16 x 10(-4) s-1, with the diastereoisomer derived from (R)-lbuprofen being the most susceptible to hydrolysis.

引用

页码：759 / 760

页数：2

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