FUNCTIONALIZED 2-AZABICYCLO(3.3.1)NONANES .14. 8-ARYL-2-AZABICYCLO[3.3.1]NONAN-7-ONES - SYNTHESIS AND RETRO-MICHAEL RING-OPENING

被引：12

作者：

BONJOCH, J

QUIRANTE, J

SOLE, D

CASTELLS, J

GALCERAN, M

BOSCH, J

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON | 1991年 / 47卷 / 25期

关键词：

D O I：

10.1016/S0040-4020(01)87110-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 8-aryl-2-azabicyclo[3.3.1]nonan-7-ones (7) by acid cyclization of 4-(3-aryl-2-oxopropyl)-2-piperidinecarbonitriles (5) is reported. Bicyclic alpha-aril-beta-amino ketones 7 easily undergo a retro-Michael ring opening to give the corresponding 2-arylcyclohexenones 8.

引用

页码：4417 / 4428

页数：12

共 25 条

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[8] FUNCTIONALIZED 2-AZABICYCLO[3.3.1]NONANES .8. A NEW SYNTHESIS OF 5-PHENYLMORPHANS
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