A CASE OF INSULIN ALLERGY - THE CRYSTALLINE HUMAN INSULIN MAY MASK ITS ANTIGENICITY

被引：13

作者：

TAKATSUKI, H ^{[1
]}

ISHII, H ^{[1
]}

YAMAUCHI, T ^{[1
]}

NAKASHIMA, N ^{[1
]}

NAGASE, S ^{[1
]}

HISATOMI, A ^{[1
]}

UMEDA, F ^{[1
]}

NAWATA, H ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 3,3-1-1 MAIDASHI,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1991年 / 12卷 / 02期

关键词：

INSULIN ALLERGY; CRYSTALLINE HUMAN INSULIN;

D O I：

10.1016/0168-8227(91)90091-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report an unusual case of insulin allergy. A 48-year-old man with non-insulin-dependent diabetes mellitus receiving biosynthetic isophane human insulin (Humulin N) developed itchy wheal-and-flare reactions at the sites of injection. When Humulin N was changed to a semi-synthetic crystalline human insulin zinc (Novolin U), the allergic reactions completely disappeared. Evaluation of his serum showed a high level of insulin-specific IgE. Skin testing with all commercially available insulins showed immediate local reactions to all agents tested except for Novolin U. In addition, decrystallized Novolin U prepared by lowering the pH with acetic acid also induced a positive reaction. These observations suggest that the crystallized structure of human insulin may mask its antigenicity for allergic reactions.

引用

页码：137 / 139

页数：3

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