DEPLETION OF 5-HT BY L-DOPA IN SPINAL-CORD AND BRAIN-STEM OF RAT

被引：23

作者：

COMMISSIONG, JW ^{[1
]}

SEDGWICK, EM ^{[1
]}

机构：

[1] DEPT BIOCHEM & PHYSIOL SCI,SOUTHAMPTON S09 3TU,ENGLAND

来源：

LIFE SCIENCES | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1016/0024-3205(79)90493-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intravenous L-DOPA caused a dose-dependent depletion of 5-HT in the lumbar region of rat spinal cord. Pretreatment with the peripheral decarboxylase inhibitor MK-486, significantly increased the 5-HT-depleting effect of acutely administered L-DOPA. Chronically administered L-DOPA (100 mg/kg per day for 3 days) had no effect on spinal 5-HT levels 24 hours after the last dose. It is concluded that the L-DOPA-mediated depletion of 5-HT from serotonergic terminals, already demonstrated to occur in the brain, also occurs in the spinal cord. This released 5-HT could be involved in mediating some of the observed physiological effects of L-DOPA in the spinal cord. © 1979.

引用

页码：83 / 86

页数：4

共 15 条

[1] EFFECT OF 5-HTP ON STATIC FUSIMOTOR ACTIVITY AND TONIC STRETCH REFLEX OF AN EXTENSOR MUSCLE
AHLMAN, H
GRILLNER, S
UDO, M
[J]. BRAIN RESEARCH, 1971, 27 (02) : 393 - &
[2] DECREASE OF CEREBRAL 5-HYDROXYTRYPTAMINE BY 3,4-DIHYDROXYPHENYLALANINE AFTER INHIBITION OF EXTRACEREBRAL DECARBOXYLASE
BARTHOLINI, G
DAPRADA, M
PLETSCHER, A
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1968, 20 (03) : 228 - +
[3] CHANGES IN DYNAMIC SENSITIVITY OF PRIMARY ENDINGS OF MUSCLE SPINDLE AFFERENTS INDUCED BY DOPA
BERGMANS, J
GRILLNER, S
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1968, 74 (04): : 629 - &
[4] PHARMACOLOGICAL STUDY OF ADRENERGIC MECHANISMS INVOLVED IN STRETCH REFLEX OF DECEREBRATE RAT
COMMISSIONG, JW
SEDGWICK, EM
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1974, 50 (03) : 365 - 374
[5] COMMISSIONG JW, 1973, J PHYSL, V232, P108
[6] Dahlstroem A, 1965, ACTA PHYSIOL SCAND S, V247, P1
[7] ELLAWAY PH, 1975, EXP BRAIN RES, V22, P142
[8] SINGLE EXTRACTION METHOD FOR SIMULTANEOUS FLUOROMETRIC DETERMINATION OF SEROTONIN DOPAMINE AND NOREPINEPHRINE IN BRAIN
FLEMING, RM
CLARK, WG
FENSTER, ED
TOWNE, JC
[J]. ANALYTICAL CHEMISTRY, 1965, 37 (06) : 692 - &
[9] Fuxe K., 1970, INT REV NEUROBIOL, V13, P93, DOI [10.1016/S0074-7742(08)60167-1, DOI 10.1016/S0074-774260167-1]
[10] INFLUENCE OF DOPA ON STATIC AND DYNAMIC FUSIMOTOR ACTIVITY TO TRICEPS SURAE OF SPINAL CAT
GRILLNER, S
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1969, 77 (04): : 490 - +

← 1 2 →