DETERMINATION OF TAXOL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY

被引：50

作者：

AURIOLA, SOK ^{[1
]}

LEPISTO, AM ^{[1
]}

NAARANLAHTI, T ^{[1
]}

LAPINJOKI, SP ^{[1
]}

机构：

[1] TECHNOL RES CTR FINLAND,SF-70211 KUOPIO,FINLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 594卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(92)80324-N

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatography-thermospray mass spectrometry method has been developed for the determination of taxol, found in the Taxus species. The compound is chromatographed by isocratic elution in 14 min and is quantitated by selected-ion recording of the protonated molecule. The method is linear over the range 1-1000 ng (1.2 pmol-1.2 nmol) of taxol per injection. The standard deviation of replicate bark samples (n = 6) was 12.8%.

引用

页码：153 / 158

页数：6

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