N-ALKYLATED 2-TRIFLUOROMETHYL-4-QUINOLONES BY ADDITION OF BASE AND AN ALKYLATING AGENT TO 2-TRIFLUOROACETYLAMINOACETOPHENONES

被引：6

作者：

COMBS, DW

REED, MS

KLAUBERT, DH

机构：

[1] The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 088690602, Route 202

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 02期

关键词：

D O I：

10.1080/00397919208021309

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Trifluoroacetylaminoacetophenones 1 are cyclized to N-alkyl-2-trifluoromethyl-4-quinolones 2 in one pot with concomitant N-alkylation in 40 to 74% yield using potassium hydroxide in acetone containing an alkylating agent.

引用

页码：323 / 326

页数：4