NOVEL THIAZOLIDINE-2,4-DIONES AS POTENT EUGLYCEMIC AGENTS

被引：75

作者：

HULIN, B

CLARK, DA

GOLDSTEIN, SW

MCDERMOTT, RE

DAMBEK, PJ

KAPPELER, WH

LAMPHERE, CH

LEWIS, DM

RIZZI, JP

机构：

[1] Central Research, Pfizer Inc, Connecticut 0634, Eastern Point Road, Groton

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 10期

关键词：

D O I：

10.1021/jm00088a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.

引用

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页码：1853 / 1864

页数：12

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