NONRECEPTOR MUSCLE ANTIBODIES IN MYASTHENIA-GRAVIS ARE OF IGG1 AND IGG4 SUBCLASSES

被引：3

作者：

HOFSTAD, H

GILHUS, NE

MATRE, R

AARLI, JA

机构：

[1] Broegelmann Research Laboratory for Microbiology, University of Bergen, Bergen

[2] Department of Neurology, University of Bergen, Bergen

[3] Department of Microbiology and Immunology, University of Bergen, Bergen

来源：

AUTOIMMUNITY | 1992年 / 12卷 / 04期

关键词：

MYASTHENIA GRAVIS; NONRECEPTOR MUSCLE ANTIBODIES; IGG SUBCLASSES; HEMAGGLUTINATION ASSAY; IMMUNOFLUORESCENCE ASSAY;

D O I：

10.3109/08916939209148469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IgG subclass distribution of non-receptor muscle antibodies was examined in 15 myasthenia gravis (MG) sera, employing an indirect haemagglutination-immunofluorescence technique. Four sera contained only IgG1, 4 contained only IgG4 and 7 contained both IgG1 and IgG4 muscle antibodies. IgG2 and IgG3 antibodies were not found. Among 11 patients with a defined thymus pathology 8 had thymoma and 3 had thymic atrophy, but there was no correlation between antibody subclass pattern and thymic pathology. Patients with both IgG1 and IgG4 antibodies tended to have the longest disease duration. We conclude that IgG non-receptor muscle antibodies in MG are of the IgG1 and/or IgG4 subclasses, irrespective of thymic pathology.

引用

页码：271 / 276

页数：6

共 22 条

[1]

Schur P.H., IgG subclasses-a review, Ann Allergy, 58, pp. 89-97, (1987)

[2]

Normansell D.E., Human immunoglobulin subclasses, Diagnost Clin Immunol, 5, pp. 115-128, (1987)

[3]

Strauss A.J.L., Seegal B.C., Hsu K.C., Burkholder P.M., Nastuk W.L., Osserman K.E., Immunofluorescence demonstration of a muscle binding, complement-fixing serum globulin fraction in myasthenia gravis, Proc Soc Exp Biol Med, 105, pp. 184-191, (1960)

[4]

Aarli J.A., Tonder O., Antiglobulin consumption test with sera from patients with myasthenia gravis, Clin exp Immunol, 7, pp. 11-21, (1970)

[5]

Djanian A.Y., Beutner E.H., Witebsky E., Tanned-cell hemagglutination test for detection of antibodies in sera of patients with myasthenia gravis, J Lab Clin Med, 63, pp. 60-70, (1964)

[6]

Carrano J.A., Swanson N.R., Dawkins R.L., An enzyme-linked immunosorbent assay for antistriational antibodies associated with myasthenia gravis and thymoma: Comparison with indirect immunofluorescence, J Immunol Methods, 59, pp. 301-314, (1983)

[7]

Ohta M., Ohta K., Mori F., Hayashi K., Nishitani H., Patients with myasthenia gravis and thymoma have anti-skeletal and anti-acetylcholine receptor antibodies simultaneously, J Clin Biochem Nutr, 6, pp. 269-279, (1989)

[8]

Zimmermann C.W., Weiss G., Antibodies not directed against the acetylcholine receptor in myasthenia gravis. An immunoblot study, J Neuroimmunol, 16, pp. 225-236, (1987)

[9]

Aarli J.A., Lefvert A.-K., Tonder O., Thymoma-specific antibodies in sera from patients with myasthenia gravis demonstrated by indirect haemagglutination, J Neuroimmunol, 1, pp. 421-427, (1981)

[10]

Mygland A., Aarli J.A., Hofstad H., Gilhus N.E., Heart muscle antibodies in myasthenia gravis, Autoimmunity, 10, pp. 263-267, (1991)

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