THE NONPEPTIDE NK1 RECEPTOR ANTAGONIST, (+/-)-CP-96,345, PRODUCES ANTINOCICEPTIVE AND ANTI-EDEMA EFFECTS IN THE RAT

被引：100

作者：

BIRCH, PJ

HARRISON, SM

HAYES, AG

ROGERS, H

TYERS, MB

机构：

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 105卷 / 03期

关键词：

(+/-)-CP-96,345; NONPEPTIDE NK1 RECEPTOR ANTAGONIST; ANTINOCICEPTION; ANTI-EDEMA;

D O I：

10.1111/j.1476-5381.1992.tb09008.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, has been evaluated for antinociceptive activity in two well-characterized inflammatory pain models in the rat. (+/-)-CP-96,345 abolished carrageenin-induced mechanical hyperalgesia, significantly reduced carrageenin-induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK1 receptor activation occurs during the induction of inflammatory pain states in the rat.

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页码：508 / 510

页数：3

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