SUSCEPTIBILITY TO CHRONIC INFECTION WITH TOXOPLASMA-GONDII DOES NOT CORRELATE WITH SUSCEPTIBILITY TO ACUTE INFECTION IN MICE

被引:73
作者
SUZUKI, Y
ORELLANA, MA
WONG, SY
CONLEY, FK
REMINGTON, JS
机构
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305
[2] JIKEI UNIV SCH MED,DEPT PARASITOL,TOKYO 105,JAPAN
[3] VET ADM MED CTR,NEUROSURG SECT,PALO ALTO,CA 94304
[4] PALO ALTO MED CLIN,RES INST,DEPT IMMUNOL & INFECT DIS,PALO ALTO,CA 94301
[5] STANFORD UNIV,MED CTR,SCH MED,DEPT SURG,DIV NEUROSURG,STANFORD,CA 94305
关键词
D O I
10.1128/IAI.61.6.2284-2288.1993
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Resistance against acute and chronic infection with Toxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after infection (acute stage). There was no mortality in the CBA/Ca mice for any of the doses. In marked contrast, CBA/Ca mice were highly sensitive to chronic infection with developing toxoplasmic encephalitis; they began dying 2 months after infection with 10 cysts of the ME49 strain, and mortality reached 53% (16 of 30) by the sixth month postinfection. No mortality (0 of 20) was observed in the chronically infected BALB/c mice. CBA/Ca mice had markedly more cysts in their brains than BALB/c mice in the chronic stage. Severe inflammatory changes were observed only in the brains of CBA/Ca mice. Interestingly, in the acute stage (the first 3 weeks), numbers of cysts in the brains were significantly greater in CBA/Ca than BALB/c mice, whereas only BALB/c mice showed mortality in that time period. No inflammatory changes were observed in brains of BALB/c mice during the acute stage of the infection. Thus, resistance against chronic infection appears to be regulated by a mechanism(s) that is different from those conferring resistance against acute infection. There was no difference in gamma interferon levels in sera between CBA/Ca and BALB/c mice during the acute stage. However, during the chronic stage, only BALB/c mice had detectable levels of gamma interferon in their sera.
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页码:2284 / 2288
页数:5
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