SECRETIN INHIBITS GASTRIC-EMPTYING IN RATS VIA A CAPSAICIN-SENSITIVE VAGAL AFFERENT PATHWAY

被引：28

作者：

RAYBOULD, HE

HOLZER, H

机构：

[1] UNIV CALIF LOS ANGELES, CURE, CTR DIGEST DIS, DEPT MED, LOS ANGELES, CA 90073 USA

[2] UNIV CALIF LOS ANGELES, BRAIN RES INST, LOS ANGELES, CA 90073 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 250卷 / 01期

关键词：

CCK (CHOLECYSTOKININ); SECRETIN; GASTRIC EMPTYING; CAPSAICIN; VAGAL AFFERENT; SPINAL AFFERENT;

D O I：

10.1016/0014-2999(93)90636-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

引用

页码：165 / 167

页数：3

共 17 条

[1] TOPOGRAPHY OF EFFERENT VAGAL INNERVATION OF THE RAT GASTROINTESTINAL-TRACT [J].