APPEARANCE OF ISOCHROMOSOME 18Q CAN BE ASSOCIATED WITH IN-VITRO IMMORTALIZATION OF HUMAN T-LYMPHOCYTES

被引：14

作者：

KALTOFT, K ^{[1
]}

PEDERSEN, CB ^{[1
]}

HANSEN, BH ^{[1
]}

THESTRUPPEDERSEN, K ^{[1
]}

机构：

[1] AARHUS UNIV,MARSELISBORG HOSP,DEPT DERMATOL,DK-8000 AARHUS,DENMARK

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 81卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)00192-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T lymphocytes cultured from a skin biopsy specimen of a patient with atopic dermatitis developed isochromosome 18q concomitant to escape from replicative senescence. Furthermore, two T-cell lines established from patients with cutaneous T-cell lymphoma also developed isochromosome 18q during continuous growth. The results indicate that a pathway leading to immortalization of human T lymphocytes could involve genes located at chromosome 18.

引用

页码：13 / 16

页数：4

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