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IN-VITRO ACTIVITY OF LEVOFLOXACIN, SINGLY AND IN COMBINATION WITH RIFAMYCIN ANALOGS, AGAINST MYCOBACTERIUM-LEPRAE

被引：10
作者：
DHOPLE, AM
IBANEZ, MA
机构：
[1] Department of Biological Sciences, Florida Institute of Technology, Melbourne
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 09期
关键词：
D O I：
10.1128/AAC.39.9.2116
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro susceptibility of Mycobacterium leprae to levofloxacin was studied by using two biochemical parameters to measure the metabolic activity of the organism, Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 mu g/ml. When combined with one of the three rifamycin analogs, synergism was obtained with KRM-1648 and rifabutin but not with rifampin.
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收藏
页码：2116 / 2119
页数：4
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