ORIGIN OF GENETIC CODE - TESTABLE HYPOTHESIS BASED ON TRANSFER-RNA STRUCTURE, SEQUENCE, AND KINETIC PROOFREADING

被引：110

作者：

HOPFIELD, JJ ^{[1
]}

机构：

[1] BELL TEL LABS INC, MURRAY HILL, NJ 07974 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1978年 / 75卷 / 09期

关键词：

D O I：

10.1073/pnas.75.9.4334

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We hypothesize that the origin of the genetic code is associated with the structure of the tRNA that existed in primal cells. The sequences of modern tRNA contain correlations which can be understood as 'fossil' evidence of the secondary structure of primal tRNA. Kinetic proofreading through diffusion can amplify a low level of intrinsic selectivity of tRNA for its amino acid. Experimental tests of the theory are suggested.

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页码：4334 / 4338

页数：5

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