PITUITARY ENDORPHIN WITH NOVEL PROPERTIES

被引：13

作者：

LOWNEY, LI ^{[1
]}

GENTLEMAN, SB ^{[1
]}

GOLDSTEIN, A ^{[1
]}

机构：

[1] STANFORD UNIV,PALO ALTO,CA 94304

来源：

LIFE SCIENCES | 1979年 / 24卷 / 25期

关键词：

D O I：

10.1016/0024-3205(79)90536-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We describe the further purification of an opioid peptide from a porcine pituitary concentrate. The peptide has typical naloxone-reversible opioid activity in the guinea pig ileum myenteric-plexus preparation and mouse vas deferens, and it inhibits stereospecific binding at opiate receptors. It is distinguished from β-endorphin and the enkephalins by its apparent molecular weight, its slow reversal with washing in the guinea pig ileum preparation, and the resistance of its biologic activity to cyanogen bromide treatment. In beef pituitary, slow-reversing, cyanogen bromide resistant activity is found principally in neurointermediate lobe. © 1979.

引用

收藏

页码：2377 / 2384

页数：8

相关论文

共 26 条

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