ACTIVATION OF THE GLYCINE SITE IN THE NMDA RECEPTOR IS NECESSARY FOR THE INDUCTION OF LTP

被引：78

作者：

BASHIR, ZI

TAM, B

COLLINGRIDGE, GL

机构：

[1] Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期

关键词：

7-Chlorokynurenate; Allosteric glycine site; d-Serine; Hippocampus; Long-term potentiation; N-Methyl-d-aspartate receptor;

D O I：

10.1016/0304-3940(90)90651-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-d-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2+-free medium and the induction of long-term potentiation (LTP) in Mg2+-containing medium. Both of these effects were reversed by d-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor. © 1990.

引用

页码：261 / 266

页数：6

共 17 条

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