STRUCTURE AND ACTIVITY OF HYDROGENATED DERIVATIVES OF (+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE (MK-801)

被引：17

作者：

LYLE, TA ^{[1
]}

MAGILL, CA ^{[1
]}

BRITCHER, SF ^{[1
]}

DENNY, GH ^{[1
]}

THOMPSON, WJ ^{[1
]}

MURPHY, JS ^{[1
]}

KNIGHT, AR ^{[1
]}

KEMP, JA ^{[1
]}

MARSHALL, GR ^{[1
]}

MIDDLEMISS, DN ^{[1
]}

WONG, EHF ^{[1
]}

ANDERSON, PS ^{[1
]}

机构：

[1] NEUROSCI RES CTR,HARLOW CM 20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 03期

关键词：

D O I：

10.1021/jm00165a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several hydrogenated derivatives of the potent NMDA antagonist 1 have been prepared and evaluated as competitive inhibitors of [3H]-1 binding. These compounds were also tested for their ability to act as noncompetitive antagonists of NMDA in vitro. These studies indicate that two aromatic rings are not strictly required for high-affinity binding or NMDA antagonism. © 1990, American Chemical Society. All rights reserved.

引用

页码：1047 / 1052

页数：6

共 20 条

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