EFFECTS OF KN-62, A SPECIFIC INHIBITOR OF CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II, ON LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPUS

被引：112

作者：

ITO, I

HIDAKA, H

SUGIYAMA, H

机构：

[1] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,NAGOYA,AICHI 466,JAPAN

[2] CHGAI PHARMACEUT CO,FUJIGOTEMBA RES LABS,GOTEMBA,JAPAN

[3] NATL INST PHYSIOL SCI,DEPT CELLULAR PHYSIOL,OKAZAKI,AICHI 444,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

LONG-TERM POTENTIATION; CALMODULIN; PROTEIN KINASE; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(91)90663-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl-4-phenylpiperazine), a specific inhibitor of calcium/calmodulin-dependent protein kinase II, were examined using rat hippocampus slices in vitro. The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. In contrast, mossy fiber LTP in CA3 regions was not affected significantly by the inhibitor.

引用

页码：119 / 121

页数：3

共 12 条

[1] ISOQUINOLINESULFONAMIDES, NOVEL AND POTENT INHIBITORS OF CYCLIC-NUCLEOTIDE DEPENDENT PROTEIN-KINASE AND PROTEIN KINASE-C
HIDAKA, H
INAGAKI, M
KAWAMOTO, S
SASAKI, Y
[J]. BIOCHEMISTRY, 1984, 23 (21) : 5036 - 5041
[2] PERTUSSIS TOXIN SUPPRESSES LONG-TERM POTENTIATION OF HIPPOCAMPAL MOSSY FIBER SYNAPSES
ITO, I
OKADA, D
SUGIYAMA, H
[J]. NEUROSCIENCE LETTERS, 1988, 90 (1-2) : 181 - 185
[3] ALLOSTERIC POTENTIATION OF QUISQUALATE RECEPTORS BY A NOOTROPIC DRUG ANIRACETAM
ITO, I
TANABE, S
KOHDA, A
SUGIYAMA, H
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 424 : 533 - 543
[4] EVIDENCE THAT THE MAJOR POSTSYNAPTIC DENSITY PROTEIN IS A COMPONENT OF A CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE
KELLY, PT
MCGUINNESS, TL
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03): : 945 - 949
[5] AN ESSENTIAL ROLE FOR POSTSYNAPTIC CALMODULIN AND PROTEIN-KINASE ACTIVITY IN LONG-TERM POTENTIATION
MALENKA, RC
KAUER, JA
PERKEL, DJ
MAUK, MD
KELLY, PT
NICOLL, RA
WAXHAM, MN
[J]. NATURE, 1989, 340 (6234) : 554 - 557
[6] PERSISTENT PROTEIN-KINASE ACTIVITY UNDERLYING LONG-TERM POTENTIATION
MALINOW, R
MADISON, DV
TSIEN, RW
[J]. NATURE, 1988, 335 (6193) : 820 - 824
[7] INHIBITION OF POSTSYNAPTIC PKC OR CAMKII BLOCKS INDUCTION BUT NOT EXPRESSION OF LTP
MALINOW, R
SCHULMAN, H
TSIEN, RW
[J]. SCIENCE, 1989, 245 (4920) : 862 - 866
[8] PROTEIN KINASE-C ACTIVITY IS NOT RESPONSIBLE FOR THE EXPRESSION OF LONG-TERM POTENTIATION IN HIPPOCAMPUS
MULLER, D
BUCHS, PA
DUNANT, Y
LYNCH, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) : 4073 - 4077
[9] DIFFERENTIAL-EFFECTS OF PHOSPHOLIPASE INHIBITORS IN LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL MOSSY FIBER SYNAPSES AND SCHAFFER COMMISSURAL SYNAPSES
OKADA, D
YAMAGISHI, S
SUGIYAMA, H
[J]. NEUROSCIENCE LETTERS, 1989, 100 (1-3) : 141 - 146
[10] MOSSY FIBER POTENTIATION AND LONG-TERM POTENTIATION INVOLVE DIFFERENT EXPRESSION MECHANISMS
STAUBLI, U
LARSON, J
LYNCH, G
[J]. SYNAPSE, 1990, 5 (04) : 333 - 335

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