ANTIEMETIC ACTION OF 5-HT-3 RECEPTOR ANTAGONISTS - REVIEW OF PRECLINICAL AND CLINICAL-RESULTS WITH ICS 205-930

被引：18

作者：

GAMSE, R

机构：

[1] Preclinical Research, Sandoz Pharma Ltd, 4002 Basle

来源：

CANCER TREATMENT REVIEWS | 1990年 / 17卷 / 2-3期

关键词：

D O I：

10.1016/0305-7372(90)90061-J

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

These results thus indicate, that ICS 205-930 is a very effective antiemetic for cancer chemotherapy-induced emesis in man. Given as a single dose prior to the chemotherapeutic agent, ICS 205-930 inhibits emesis and nausea for at least 24 hr. Together with the lack of extrapyramidal side-effects, these properties of ICS 205-930 indicate a clear superiority to the current therapeutic standard metoclopramide. © 1990.

引用

收藏

页码：301 / 305

页数：5

相关论文

共 20 条

[1] NEUROPHARMACOLOGY OF EMESIS INDUCED BY ANTI-CANCER THERAPY [J].

ANDREWS, PLR ;

RAPEPORT, WG ;

SANGER, GJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (09) :334-341

[2] THE ANTI-EMETIC POTENTIAL OF THE 5-HYDROXYTRYPTAMINE3 RECEPTOR ANTAGONIST BRL-43694 [J].

BERMUDEZ, J ;

BOYLE, EA ;

MINER, WD ;

SANGER, GJ .

BRITISH JOURNAL OF CANCER, 1988, 58 (05) :644-650

[3]

COHEN ML, 1989, J PHARMACOL EXP THER, V248, P197

[4] 5-HYDROXYTRYPTAMINE M-RECEPTOR ANTAGONISM TO PREVENT CISPLATIN-INDUCED EMESIS [J].

COSTALL, B ;

DOMENEY, AM ;

NAYLOR, RJ ;

TATTERSALL, FD .

NEUROPHARMACOLOGY, 1986, 25 (08) :959-961

[5] 5-HT3 RECEPTORS AND CYTOTOXIC DRUG-INDUCED VOMITING [J].

FOZARD, JR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (02) :44-45

[6]

GYLYS JA, 1988, J PHARMACOL EXP THER, V244, P830

[7] THE ROLE OF THE ABDOMINAL VISCERAL INNERVATION AND 5-HYDROXYTRYPTAMINE M-RECEPTORS IN VOMITING INDUCED BY THE CYTO-TOXIC DRUGS CYCLOPHOSPHAMIDE AND CISPLATIN IN THE FERRET [J].

HAWTHORN, J ;

OSTLER, KJ ;

ANDREWS, PLR .

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1988, 73 (01) :7-21

[8] 5-HT3 RECEPTOR ANTAGONISTS INJECTED INTO THE AREA POSTREMA INHIBIT CISPLATIN-INDUCED EMESIS IN THE FERRET [J].

HIGGINS, GA ;

KILPATRICK, GJ ;

BUNCE, KT ;

JONES, BJ ;

TYERS, MB .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (01) :247-255

[9]

LEIBUNDGUT U, 1987, LANCET, V1, P1198

[10] BLOCKADE OF 5-HYDROXYTRYPTAMINE3 RECEPTORS PREVENTS CISPLATIN-INDUCED BUT NOT MOTION-INDUCED OR XYLAZINE-INDUCED EMESIS IN THE CAT [J].

LUCOT, JB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (01) :207-210