THE GENETICS OF MULTIPLE ENDOCRINE NEOPLASIA (MEN)

被引：8

作者：

CALENDER, A

SCHUFFENECKER, I

LENOIR, GM

机构：

来源：

HORMONE RESEARCH | 1992年 / 38卷

关键词：

MULTIPLE ENDOCRINE NEOPLASIA; GENETICS; GENE; PREDICTIVE SCREENING;

D O I：

10.1159/000182587

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple Endocrine Neoplasia (MEN) refers to the family of diseases characterized by hyperplasia and/or tumoral proliferation in various organs derived from the neural crest. MEN are transmitted in an autosomal dominant fashion in affected pedigrees with a high degree of penetrance. MEN 1 and MEN 2A/B loci have recently been mapped, respectively, to chromosomes 11 and 10 by linkage analysis using polymorphic DNA markers. These discoveries will lead (1) to a rapid understanding of the physiopathological pathway determining such syndromes and (2) to major clinical impact through the genetic screening.

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页码：16 / 23

页数：8

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