EVIDENCE FOR THE PRESENCE OF EXCITATORY ADENOSINE-A2 RECEPTORS IN THE RAT HIPPOCAMPUS

被引：115

作者：

SEBASTIAO, AM

RIBEIRO, JA

机构：

[1] Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

CGS; 21680; 3,7-DIMETHYL-1-PROPARGYLXANTHINE; ADENOSINE-A2; RECEPTOR; HIPPOCAMPAL SLICE; CA1 POPULATION SPIKE;

D O I：

10.1016/0304-3940(92)90467-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The A2 adenosine receptor agonist, CGS 21680 in nanomolar concentrations, reversibly increased in a concentration-dependent manner the amplitude of orthodromically-evoked population spikes recorded from the CA1 pyramidal cell layer of rat hippocampal slices. The adenosine receptor antagonist, 3,7-dimethyl-1-propargylxanthine (DM PX, 10-mu-M), which has selectivity for A2 adenosine receptors, prevented this excitatory effect of CGS 21680. These results suggest that A2 adenosine receptors are present in the rat hippocampus and that activation of these receptors enhance hippocampal excitability.

引用

页码：41 / 44

页数：4

共 18 条

[1] ADENOSINE-A1 AND NON-A1 RECEPTORS - INTRACELLULAR ANALYSIS OF THE ACTIONS OF ADENOSINE AGONISTS AND ANTAGONISTS IN RAT HIPPOCAMPAL-NEURONS [J].