STRESSOR-SPECIFIC INCREASE OF VASOPRESSIN MESSENGER-RNA IN PARAVENTRICULAR HYPOPHYSIOTROPHIC NEURONS

被引：26

作者：

BARTANUSZ, V

AUBRY, JM

STEIMER, T

BAFFI, J

KISS, JZ

机构：

[1] UNIV GENEVA,SCH MED,CMU,DEPT MORPHOL,CH-1211 GENEVA 4,SWITZERLAND

[2] IUPG,DEPT PSYCHIAT,GENEVA,SWITZERLAND

[3] SEMMELWEIS UNIV MED,SCH MED,DEPT ANAT 1,BUDAPEST,HUNGARY

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

IN SITU HYBRIDIZATION; STRESS; IMMOBILIZATION; OPEN-FIELD; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CRF; VASOPRESSIN; MESSENGER-RNA;

D O I：

10.1016/0304-3940(94)90232-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cellular levels of vasopressin (VP) and corticotropin-releasing factor (CRF) RNA transcripts were determined in hypophysiotrophic neurons after open-field and immobilization stress using quantitative in situ hybridization. We found that 8 min open-field stress is sufficient to produce a significant up-regulation of CRF mRNA, without any concomitant changes in the level of VP mRNA. In contrast, 8 min immobilization stress resulted in an increased labeling density of both CRF and VP mRNAs. These results suggest that the level of CRF and VP transcripts in parvicellular hypophysiotrophic neurons is differentially regulated in a stresser-specific manner.

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页码：35 / 38

页数：4

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