ETHANOL INDUCES FOS IMMUNOREACTIVITY IN THE RAT-BRAIN

被引：7

作者：

CHANG, SL ^{[1
]}

PATEL, NA ^{[1
]}

ROMERO, AA ^{[1
]}

KENIG, V ^{[1
]}

机构：

[1] UNIV NEW ORLEANS,DEPT PSYCHOL,NEW ORLEANS,LA 70148

来源：

REGULATORY PEPTIDES | 1994年 / 54卷 / 01期

关键词：

D O I：

10.1016/0167-0115(94)90384-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of the FOS proto-oncogene protein has been used as an anatomical marker of activated brain areas. Detection of FOS immunoreactivity can provide information about the sites of action of various stimuli at the level of single cell resolution. Following the intraperitoneal injection of ethanol (16% W/V), FOS immunoreactivity was induced in several rat brain areas including the bed nucleus, hypothalamic paraventricular nucleus, central nucleus of the amygdala, Edinger-Wesphal nucleus, locus coeruleus nucleus, parabrachial nucleus. The induction was dose-dependent, and the length of activation time was different in each nucleus. FOS immunoreactivity in the supraoptic nucleus only appeared with injection of the higher concentration of ethanol. Repeated administration of ethanol twice daily for 17 days resulted in a desensitization of FOS immunoreactivity in these nuclei. These data suggest that the induction of FOS immunoreactivity can be used to determine the sites at which ethanol acts on the brain, and may provide important information about the mechanisms underlying the tolerance and physical dependence of alcohol usage.

引用

页码：51 / 52

页数：2