An early lesion of the lateral septal nuclei produces changes in the forced swim test depending on gender

被引：26

作者：

Contreras, CM

LaraMorales, H

MolinaHernandez, M

Saavedra, M

ArrellinRosas, G

机构：

[1] UNIV VERACRUZ, INST NEUROETOL, CATEMACO, MEXICO

[2] Univ Nacl Autonoma Mexico, LAB NEUROFARMACOL, DEPT FISIOL, INST INVEST BIOMED, MEXICO CITY, DF, MEXICO

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 08期

关键词：

clomipramine; early lesions; electroconvulsive shock; forced swim test; lateral septal nuclei; plasticity;

D O I：

10.1016/0278-5846(95)00266-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Several pharmacological maneuvers in very young rats produce later changes resembling human depression. 2. Rats were submitted to a wide lesion in lateral septal region at 8th day after birth and forced to swim at maturity. 3. Male lesioned group showed the highest amount of immobility; whereas, female sham lesion group showed a greater response to treatments. 4. A gender-dependent sensitivity to early lateral septal nucleus lesions and to antidepressants are concluded.

引用

收藏

页码：1277 / 1284

页数：8

相关论文

共 20 条

[1] ESTROGEN-RECEPTOR IN RAT-BRAIN - PRESENCE IN THE HIPPOCAMPAL-FORMATION [J].

BETTINI, E ;

POLLIO, G ;

SANTAGATI, S ;

MAGGI, A .

NEUROENDOCRINOLOGY, 1992, 56 (04) :502-508

[2] STEROID-HORMONE EFFECTS ON NMDA RECEPTOR-BINDING AND NMDA RECEPTOR MESSENGER-RNA LEVELS IN THE HYPOTHALAMUS AND CEREBRAL-CORTEX OF THE ADULT-RAT [J].

BRANN, DW ;

ZAMORANO, PL ;

CHORICH, LP ;

MAHESH, VB .

NEUROENDOCRINOLOGY, 1993, 58 (06) :666-672

[3] SUSTAINED ELEVATION IN HIPPOCAMPAL NGF-LIKE BIOLOGICAL-ACTIVITY FOLLOWING MEDIAL SEPTAL-LESIONS IN THE RAT [J].

COLLINS, F ;

CRUTCHER, KA .

BRAIN RESEARCH, 1989, 490 (02) :355-360

[4]

CONTRERAS C M, 1991, Boletin de Estudios Medicos y Biologicos Universidad Nacional Autonoma de Mexico, V39, P3

[5] CHRONIC CLOMIPRAMINE INCREASES FIRING RATE IN LATERAL SEPTAL NUCLEI OF THE RAT [J].

CONTRERAS, CM ;

MARVAN, ML ;

ALCALAHERRERA, V ;

GUZMANSAENZ, MA .

PHYSIOLOGY & BEHAVIOR, 1990, 48 (04) :551-554

[6] SLEEP-DEPRIVATION IS A LESS POTENT AGENT THAN CLOMIPRAMINE IN INCREASING FIRING RATE IN LATERAL SEPTAL NEURONS IN THE RAT [J].

CONTRERAS, CM ;

MARVAN, ML ;

ALCALAHERRERA, V .

NEUROPSYCHOBIOLOGY, 1993, 27 (02) :83-85

[7] EPIDEMIOLOGY OF SUICIDE [J].

FARMER, R .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1992, 6 :1-11

[8] INCREASED ADULT BEHAVIORAL DESPAIR IN RATS NEONATALLY EXPOSED TO DESIPRAMINE OR ZIMELDINE - AN ANIMAL-MODEL OF DEPRESSION [J].

HILAKIVI, LA ;

HILAKIVI, I .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 28 (03) :367-369

[9] AN INVIVO ELECTROPHYSIOLOGICAL STUDY OF THE ONTOGENY OF EXCITATORY AND INHIBITORY PROCESSES IN THE RAT HIPPOCAMPUS [J].

MICHELSON, HB ;

LOTHMAN, EW .

DEVELOPMENTAL BRAIN RESEARCH, 1989, 47 (01) :113-122

[10] ANTIDEPRESSANTS INDUCE REGENERATION OF CATECHOLAMINERGIC AXON TERMINALS IN THE RAT CEREBRAL-CORTEX [J].

NAKAMURA, S .

NEUROSCIENCE LETTERS, 1990, 111 (1-2) :64-68