2,6-DIALKYLPIPERAZINES .4. 1-PROPIONYL-4-SUBSTITUTED CIS-2,6-DIMETHYLPIPERAZINES STRUCTURALLY RELATED TO ANALGETIC 8-ACYL-3,8-DIAZABICYCLO[3.2.1]OCTANES

The high analgetic activity of 3-methyl- and 3-propionyl-3,8-diazabicyclo[3.2.1]octanes has been previously reported. The present paper deals with the synthesis of some piperazines structurally related to the analgetic diazabicyclooctanes but lacking their endoethylenic bridge. The most active analgetics in the piperazine series, namely, 2,6-dimethyl- and 2,2,6-trimethyl-1-propionyl-4-cinnamylpiperazines, are greatly inferior to the corresponding diazabicyclooctanes; the break of the endoethylenic bridge is unfavorable to the analgetic activity. © 1968, American Chemical Society. All rights reserved.