A REINVESTIGATION OF ORIGIN OF CELLS IN GRAFTED TUMOURS USING MOUSE T6 MARKER CHROMOSOME

Using a mouse chromosome marker technique, it was found that host cells were rare in transplants of a chemically induced sarcoma, and absent in a human adenovirus type 12‐induced tumour. However, host cells were found in four of nine transplants of a Moloney virus‐induced lymphoma and, in three of these, they constituted the majority of mitotic cells. The nature of the host cells, and the possible importance of the part played by infective virus particles in the continued growth of this tumour, are discussed. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company