MINIMIZATION OF POLYPEPTIDE ENERGY .4. FURTHER STUDIES OF GRAMICIDIN S

被引：23

作者：

MOMANY, FA

VANDERKO.G

TUTTLE, RW

SCHERAGA, HA

机构：

[1] Department of Chemistry, Cornell University, Ithaca

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 02期

关键词：

D O I：

10.1021/bi00830a041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using energy minimization techniques previously described, the structure of gramicidin S proposed by Hodgkin and Oughton and by Schwyzer was taken as a starting point for the minimization procedure.After energy minimization, the resulting structure differed from the initial one, and had an energywhich was con siderably lower than that of any structure of gramicidin S heretofore reported. However, like the Hodgkin- Oughton-Schwyzer structure from which it was derived, it is consistent with the chemical evidence. © 1969, American Chemical Society. All rights reserved.

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页码：744 / &

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