INVIVO EFFECTS OF SUMATRIPTAN (GR-43175) ON EXTRACELLULAR LEVELS OF 5-HT IN THE GUINEA-PIG

被引：70

作者：

SLEIGHT, AJ ^{[1
]}

CERVENKA, A ^{[1
]}

PEROUTKA, SJ ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,DEPT NEUROL,STANFORD,CA 94305

来源：

NEUROPHARMACOLOGY | 1990年 / 29卷 / 06期

关键词：

5-HT release; 5-HT terminal autoreceptor; 5-HT[!sub]ID[!/sub] receptors; intracerebral dialysis;

D O I：

10.1016/0028-3908(90)90061-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of sumatriptan, a selective 5-HTID receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by intracerebral dialysis. A constant infusion of sumatriptan (10-8-10-7 M) dose-dependently reduced extracellular levels of 5-HT (e.g. 80 ± 2% decrease from control levels of 5-HT at 10-7 M). Peripheral administration of sumatriptan (50 μg/kg i.p. and 500 μg/kg i.p.) had no effect on extracellular levels of 5-HT in the frontal cortex. These data suggest that sumatriptan, when infused into the brain, inhibits the release of 5-HT by stimulating 5-HT autoreceptors and that the putative acute anti-migraine effects of sumatriptan are likely to be mediated by peripheral mechanisms. © 1990.

引用

页码：511 / 513

页数：3

共 8 条

[1]

[Anonymous], 1967, STEREOTAXIC ATLAS FO

[2]

DOENICKE A, 1988, LANCET, V1, P1309

[3] SPECIES-DIFFERENCES IN THE PHARMACOLOGY OF TERMINAL 5-HT AUTORECEPTORS IN MAMMALIAN BRAIN [J].