EPIDERMAL HELIX - MODEL FOR THE BILAYER COUPLE PHENOMENON

被引：1

作者：

SHELLEY, WB ^{[1
]}

JUHLIN, L ^{[1
]}

机构：

[1] UNIV UPPSALA,SCH MED,DEPT DERMATOL,S-75105 UPPSALA,SWEDEN

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1979年 / 265卷 / 02期

关键词：

Contraction; Epidermis; Helix; Histamine; Osmosis;

D O I：

10.1007/BF00407879

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Narrow strips of isolated epidermis rapidly assume a helical conformation when placed in a dilute hypotonic aqueous solution of histamine as a free base. The same helical formations could be induced by dilute hypotonic solutions of alkalis or acids. This coiling resulted from damage to the malpighian cells, with consequent asymmetric osmotic swelling of the epidermis, thus producing torsional forces on the stratum corneum. In essence, the epidermal helix proved to be a pH dependent, osmotically induced, bilayer couple phenomenon. © 1979 Springer-Verlag.

引用

页码：145 / 152

页数：8

共 4 条

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LUBBEMEIER, A ;

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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1977, 372 (03) :259-268

[2]

JUHLIN L, 1977, ACTA DERM-VENEREOL, V57, P289

[3]

NAGO S, 1972, ACTA DERMATO VENEREO, V52, P11

[4] BIOLOGICAL-MEMBRANES AS BILAYER COUPLES - MOLECULAR MECHANISM OF DRUG-ERYTHROCYTE INTERACTIONS [J].

SHEETZ, MP ;

SINGER, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (11) :4457-4461

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