FORMATION OF PHOSPHATIDYLINOSITOL BY ACYLATION OF 2-ACYL-SN-GLYCERO-3-PHOSPHORYLINOSITOL IN RAT-LIVER MICROSOMES

被引：22

作者：

HOLUB, BJ

PIEKARSKI, J

机构：

[1] Department of Nutrition, College of Biological Science, University of Guelph, Guelph, N1G 2W1, Ontario

来源：

LIPIDS | 1979年 / 14卷 / 06期

关键词：

D O I：

10.1007/BF02533526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conversion of 2-acyl-sn-glycero-3-phosphorylinositol into phosphatidylinositol via acyl-CoA: 2-acyl-sn-glycero-3-phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl-CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1-position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl-CoA: 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase under certain assay conditions. © 1979 American Oil Chemists' Society.

引用

页码：529 / 532

页数：4

共 12 条

[1]

BAKER RR, 1973, J BIOL CHEM, V248, P7060

[2] STRUCTURAL AND METABOLIC INTERRELATIONSHIPS AMONG GLYCEROPHOSPHATIDES OF RAT-LIVER IN-VIVO [J].